diff --git a/src/material/dialog/dialog-content-directives.ts b/src/material/dialog/dialog-content-directives.ts
index 261fc1ba17b7..190bcb2664b4 100644
--- a/src/material/dialog/dialog-content-directives.ts
+++ b/src/material/dialog/dialog-content-directives.ts
@@ -70,6 +70,12 @@ export class MatDialogClose implements OnInit, OnChanges {
   }
 
   _onButtonClick(event: MouseEvent) {
+    // For compatibility with `disabledInteractive`. We don't need to handle plain `disabled`,
+    // because disabled buttons don't dispatch click events by default. See #33366.
+    if (this._elementRef.nativeElement.getAttribute('aria-disabled') === 'true') {
+      return;
+    }
+
     // Determinate the focus origin using the click event, because using the FocusMonitor will
     // result in incorrect origins. Most of the time, close buttons will be auto focused in the
     // dialog, and therefore clicking the button won't result in a focus change. This means that
diff --git a/src/material/dialog/dialog.spec.ts b/src/material/dialog/dialog.spec.ts
index 504a0a7aeadc..47ba393a2ba5 100644
--- a/src/material/dialog/dialog.spec.ts
+++ b/src/material/dialog/dialog.spec.ts
@@ -1835,6 +1835,25 @@ describe('MatDialog', () => {
         );
       });
 
+      it('should not close when clicking on an aria-disabled close button', async () => {
+        expect(overlayContainerElement.querySelectorAll('.mat-mdc-dialog-container').length).toBe(
+          1,
+        );
+
+        const closeButton = overlayContainerElement.querySelector(
+          'button[mat-dialog-close]',
+        ) as HTMLElement;
+
+        closeButton.setAttribute('aria-disabled', 'true');
+        closeButton.click();
+        viewContainerFixture.detectChanges();
+        await viewContainerFixture.whenStable();
+
+        expect(overlayContainerElement.querySelectorAll('.mat-mdc-dialog-container').length).toBe(
+          1,
+        );
+      });
+
       it('should not close if [mat-dialog-close] is applied on a non-button node', () => {
         expect(overlayContainerElement.querySelectorAll('.mat-mdc-dialog-container').length).toBe(
           1,